Comparison of the Effects of Soy Protein and Whey Protein Supplementation during Exercise: a Systematic Review
DOI:
https://doi.org/10.17921/2447-8938.2019v21n4p397-403Resumo
Abstract
The interest of the supplementation market for the soy protein consumption to optimize physical and metabolic performance after exercise is increasing. However, evidence suggests that the soy protein ingestion has lower anabolic properties when compared with whey protein. The purpose of this systematic review was to compare the effects of whey protein and soy protein supplementation on the muscle functions maintenance after exercise. This review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles were searched for in the Pubmed database and included studies comparing the effects of soy protein and whey protein consumption on protein synthesis, lean mass gain and oxidative stress reduction in response to endurance or resistance training. Thirteen trials were included in this review. The results showed that the whey protein consumption is superior to that of soy protein with respect to protein synthesis and lean mass gain, but soy protein showed superior results in reducing oxidative stress. Future research comparing both soy and whey protein are needed to define protein source to be used in nutritional interventions to protein synthesis, lean mass gain and oxidative stress in different populations.
Keywords: Soybean Proteins. Milk Proteins. Protein Biosynthesis. Hypertrophy.
Resumo
O interesse do mercado de suplementação pelo consumo de proteína de soja para otimizar o desempenho físico e metabólico após o exercício está aumentando. No entanto, evidências sugerem que a ingestão da proteína de soja tem propriedades anabólicas mais baixas quando comparada à proteína do soro do leite. O objetivo desta revisão sistemática foi comparar os efeitos da suplementação com whey protein e proteína de soja na manutenção das funções musculares após o exercício. Esta revisão foi realizada usando os Itens de Relatório Preferidos para Revisões Sistemáticas e Meta-Análises (PRISMA). Os artigos foram pesquisados na base de dados Pubmed e incluíram estudos comparando os efeitos da proteína de soja e do consumo de proteínas do soro na síntese protéica, ganho de massa magra e redução do estresse oxidativo em resposta ao treinamento de resistência ou resistência. Treze ensaios foram incluídos nesta revisão. Os resultados mostraram que o consumo de proteína de soro é superior ao da proteína de soja em relação à síntese protéica e ao ganho de massa magra, mas a proteína de soja apresentou resultados superiores na redução do estresse oxidativo. Pesquisas futuras comparando a soja e a proteína do soro do leite são necessárias para definir a fonte protéica a ser usada em intervenções nutricionais para a síntese protéica, ganho de massa magra e estresse oxidativo em diferentes populações.
Palavras-chave: Proteínas de Soja. Proteínas do Leite. Biossíntese de Proteínas. Hipertrofia.
Referências
Williamson DL, Kubica N, Kimball SR, Jefferson LS. Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol 2006;573(2):497-510. doi: 10.1113/jphysiol.2005.103481.
Kerksick CM, Rasmussen CJ, Lancaster SL, Magu B, Smith P, Melton C, et al. The effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resistance training. J Strength Cond Res 2006;20(3):643. doi:10.1519/R-17695.1
Elia D, Stadler K, Horváth V, Jakus J. Effect of soy-and whey protein-isolate supplemented diet on the redox parameters of trained mice. Euro J Nutr 2006;45(5):259-66. doi:10.1007/s00394-006-0593-z.
Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, Rasmussen BB. An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol-Endocrinol Metabol 2010;298(5):E1011-E8. doi: 10.1152/ajpendo.00690.2009.
Tipton KD, Elliott TA, Cree MG, Aarsland AA, Sanford AP, Wolfe RR. Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise. American J Physiol-Endocrinol Metabol 2007;292(1):E71-E76. doi: 10.1152/ajpendo.00166.2006
Burke DG, Chilibeck PD, Davidson KS, Candow DG, Farthing J, Smith-Palmer T. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metabol 2001;11(3):349-64.
Teixeira KR, Silva ME, Lima WG, Pedrosa ML, Haraguchi FK. Whey protein increases muscle weight gain through inhibition of oxidative effects induced by resistance exercise in rats. Nutr Res 2016;36(10):1081-9. doi: 10.1016/j.nutres.2016.08.003.
Thomson RL, Brinkworth GD, Noakes M, Buckley JD. Muscle strength gains during resistance exercise training are attenuated with soy compared with dairy or usual protein intake in older adults: a randomized controlled trial. Clin Nutr 2016;35(1):27-33. doi: 10.1016/j.clnu.2015.01.018.
Flik G, Huising M, Gorissen M. Peptides and proteins regulating food intake: a comparative view. Animal Biol 2006;56(4):447-73. doi: https://doi.org/10.1163/157075606778967829.
Hodgson JM, Croft KD, Puddey IB, Mori TA, Beilin LJ. Soybean isoflavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum. J Nutr Biochem 1996;7(12):664-9. doi: https://doi.org/10.1016/S0955-2863(96)00133-7.
Candow DG, Burke NC, Smith-Palmer T, Burke DG. Effect of whey and soy protein supplementation combined with resistance training in young adults. Int J Sport Nutr Exerc Metabol 2006;16(3):233-44.
Brown EC, DiSilvestro RA, Babaknia A, Devor ST. Soy versus whey protein bars: effects on exercise training impact on lean body mass and antioxidant status. Nutr J 2004;3(1):22. doi: 10.1186/1475-2891-3-22
Kalman D, Feldman S, Martinez M, Krieger DR, Tallon MJ. Effect of protein source and resistance training on body composition and sex hormones. J Int Soc Sports Nutr 2007;4(1):4. doi: 10.1186/1550-2783-4-4.
Mobley C, Haun C, Roberson P, Mumford P, Romero M, Kephart WJ, et al. Effects of whey, soy or leucine supplementation with 12 weeks of resistance training on strength, body composition, and skeletal muscle and adipose tissue histological attributes in college-aged males. Nutrients 2017;9(9):972. doi: 10.3390/nu9090972.
Volek JS, Volk BM, Gómez AL, Kunces LJ, Kupchak BR, Freidenreich DJ, et al. Whey protein supplementation during resistance training augments lean body mass. J Am College Nutr 2013;32(2):122-35. doi: 10.1080/07315724.2013.793580.
Aristizabal JC, Freidenreich DJ, Volk BM, Kupchak BR, Saenz C, Maresh CM, et al. Effect of resistance training on resting metabolic rate and its estimation by a dual-energy X-ray absorptiometry metabolic map. Euro J Clin Nutr 2015;69(7):831. doi: 10.1038/ejcn.2014.216.
Yang Y, Churchward-Venne TA, Burd NA, Breen L, Tarnopolsky MA, Phillips SM. Myofibrillar protein synthesis following ingestion of soy protein isolate at rest and after resistance exercise in elderly men. Nutr Metabol 2012;9(1):57. doi: 10.1186/1743-7075-9-57.
Mitchell CJ, Della Gatta PA, Petersen AC, Cameron-Smith D, Markworth JF. Soy protein ingestion results in less prolonged p70S6 kinase phosphorylation compared to whey protein after resistance exercise in older men. J Int Soc Sports Nutr 2015;12(1):6. doi: 10.1186/s12970-015-0070-2.
Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol 2009;107(3):987-92. doi: 10.1152/japplphysiol.00076.2009.
Kanda A, Nakayama K, Sanbongi C, Nagata M, Ikegami S, Itoh H. Effects of whey, caseinate, or milk protein ingestion on muscle protein synthesis after exercise. Nutrients 2016;8(6):339. doi: 10.3390/nu8060339.
Anthony TG, McDaniel BJ, Knoll P, Bunpo P, Paul GL, McNurlan MA. Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats. J Nutr 2007;137(2):357-62. doi: 10.1093/jn/137.2.357.
Box W, Hill S, Disilvestro RA. Soy intake plus moderate weight resistance exercise: effects on serum concentrations of lipid peroxides in young adult women. J Sports Med Phys Fitness 2005;45(4):524.
Hill S, Box W, Disilvestro RA. Moderate intensity resistance exercise, plus or minus soy intake: effects on serum lipid peroxides in young adult males. Int J Sport Nutr Exerc Metabol 2004;14(2):125-32.
Spiering BA, Kraemer WJ, Anderson JM, Armstrong LE, Nindl BC, Volek JS, et al. Resistance exercise biology: manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Med 2008;38(7):527-40. doi: 10.2165/00007256-200838070-00001.
Atherton PJ, Smith K. Muscle protein synthesis in response to nutrition and exercise. J Physiol 2012;590(5):1049-57. doi: 10.1113/jphysiol.2011.225003.
Reynolds TH, Bodine SC, Lawrence JC. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem 2002;277(20):17657-62. doi: 10.1074/jbc.M201142200.
Phillips SM, Hartman JW, Wilkinson SB. Dietary protein to support anabolism with resistance exercise in young men. J Am College Nutr 2005;24(2):134S-9S.
Mcglory C, Devries MC, Phillips SM. Skeletal muscle and resistance exercise training; the role of protein synthesis in recovery and remodeling. J. Appl Physiol 2016;122(3):541-8. doi: 10.1152/japplphysiol.00613.2016.
Kumar V, Atherton PJ, Selby A, Rankin D, Williams J, Smith K, et al. Muscle protein synthetic responses to exercise: effects of age, volume, and intensity. J Gerontol 2012;67(11):1170-7. doi: 10.1093/gerona/gls141.
Butteiger DN, Cope M, Liu P, Mukherjea R, Volpi E, Rasmussen BB, et al. A soy, whey and caseinate blend extends postprandial skeletal muscle protein synthesis in rats. Clin Nutr 2013;32(4):585-91. doi: 10.1016/j.clnu.2012.10.001.
Van Vliet S, Burd NA, Van Loon LJC. The skeletal muscle anabolic response to plant-versus animal-based protein consumption. J Nutr 2015;145(9):1981-91. doi: 10.3945/jn.114.204305.
Tang JE, Phillips SM. Maximizing muscle protein anabolism: the role of protein quality. Curr Opin Clin Nutr Metab Care 2009;12(1):66-71. doi: 10.1097/MCO.0b013e32831cef75.
Anthony JC, Anthony TG, Layman DK. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr 1999;129(6):1102-6. doi:10.1093/jn/129.6.1102
Lane MT, Herda TJ, Fry AC, Cooper MA, Andre MJ, Gallagher PM. Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey. Biol Sport 2017;34(2):197. doi: 10.5114/biolsport.2017.65339
Lollo PCB, Silva LBC, Batista TM, Morato PN, Moura CS, Cruz AG, et al. Effects of whey protein and casein plus leucine on diaphragm the mTOR pathway of sedentary, trained rats. Food Res Int 2012;49(1):416-24. doi:10.1016/j.foodres.2012.07.024
Bos C, Metges CC, Gaudichon C, Petzke KJ, Pueyo ME, Morens C, et al. Postprandial kinetics of dietary amino acids are the main determinant of their metabolism after soy or milk protein ingestion in humans. J Nutr 2003;133(5):1308-15. doi: 10.1093/jn/133.5.1308
Tipton KD, Ferrando AA, Phillips SM, Doyle Junior D, Wolfe RR. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol- Endocrinol Metabol 1999;276(4):E628-E34. doi:10.1152/ajpendo.1999.276.4.E628.
Disilvestro RA, Nutrition H. Antioxidant actions of soya. Leatherhead Food RA Food Ind J 2001;4:210-20.
Liu J, Chang SKC, Wiesenborn D. Antioxidant properties of soybean isoflavone extract and tofu in vitro and in vivo. J Agric Food Chem 2005;53(6):2333-40. doi:10.1021/jf048552e
Erba D, Casiraghi MC, Martinez-Conesa C, Goi G, Massaccesi L. Isoflavone supplementation reduces DNA oxidative damage and increases O-β-N-acetyl-D-glucosaminidase activity in healthy women. Nutr Res 2012;32(4):233-40. doi: 10.1016/j.nutres.2012.03.007.
Yoon G, Park S. Antioxidant action of soy isoflavones on oxidative stress and antioxidant enzyme activities in exercised rats. Nutr Res Pract 2014;8(6):618-24. doi: 10.4162/nrp.2014.8.6.618.
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